Compile Data Set for Download or QSAR
maximum 50k data
Found 99 of ec50 for PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA
having polymerids = 575,633,50001175 and
complexids = 50000329,50000308,50000338,50000002,50000008,50000319
LigandPNGBDBM50507495(CHEMBL4445464)
Affinity DataEC50:  0.410nMAssay Description:Inhibition of human PD-1 expressed in rat PBMCs/human PD-L1 expressed in MDA-MB-231 cells protein-protein interaction assessed as increase in PBMCs p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50507495(CHEMBL4445464)
Affinity DataEC50:  0.720nMAssay Description:Inhibition of human PD-1/PD-L1 interactionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50409501(CHEMBL5278637)
Affinity DataEC50: <1nMAssay Description:Inhibition of rat liver Dihydrofolate reductase.More data for this Ligand-Target Pair
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LigandPNGBDBM50613791(CHEMBL4092332)
Affinity DataEC50:  1nMAssay Description:Positive allosteric modulation of rat recombinant GABAA alpha6beta3gamma2 receptor expressed in Xenopus laevis oocytes assessed as increase in GABA-i...More data for this Ligand-Target Pair
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LigandPNGBDBM50611348(CHEMBL5289751)
Affinity DataEC50:  2nMAssay Description:Activation of caspase 3/7 in human 22Rv1 cells by Caspase-Glo reagent based analysisMore data for this Ligand-Target Pair
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LigandPNGBDBM50613791(CHEMBL4092332)
Affinity DataEC50:  4nMAssay Description:Positive allosteric modulation of rat recombinant GABAA gamma2beta3alpha1-beta3alpha6 receptor expressed in Xenopus laevis oocytes assessed as increa...More data for this Ligand-Target Pair
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TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242740(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)
Affinity DataEC50:  6nMAssay Description:Inhibition of PDGFRbeta by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50613797(CHEMBL4087909)
Affinity DataEC50:  8nMAssay Description:Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha6-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as increa...More data for this Ligand-Target Pair
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LigandPNGBDBM50613791(CHEMBL4092332)
Affinity DataEC50:  9nMAssay Description:Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha6-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as increa...More data for this Ligand-Target Pair
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LigandPNGBDBM50615253(CHEMBL5278539)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
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LigandPNGBDBM50613796(CHEMBL5269339)
Affinity DataEC50:  10nMAssay Description:Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha6-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as increa...More data for this Ligand-Target Pair
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LigandPNGBDBM50613792(CHEMBL5275087)
Affinity DataEC50:  13nMAssay Description:Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha6-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as increa...More data for this Ligand-Target Pair
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LigandPNGBDBM50608555(CHEMBL5269165)
Affinity DataEC50:  15nMAssay Description:Inhibition of HDAC in human HeLa cells using FLUOR DE LYS-SIRT1 as fluorogenic substrate incubated for 4 hrs by spectrophotometer based analysisMore data for this Ligand-Target Pair
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LigandPNGBDBM50613793(CHEMBL5270302)
Affinity DataEC50:  23nMAssay Description:Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha6-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as increa...More data for this Ligand-Target Pair
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LigandPNGBDBM50613795(CHEMBL5266751)
Affinity DataEC50:  28nMAssay Description:Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha6-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as increa...More data for this Ligand-Target Pair
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LigandPNGBDBM50612445(CHEMBL5282110)
Affinity DataEC50:  43nMAssay Description:Inhibition of HDAC in human HeLa cells using FLUOR DE LYS-SIRT1 as fluorogenic substrate incubated for 4 hrs by spectrophotometer based analysisMore data for this Ligand-Target Pair
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LigandPNGBDBM50258549((S)-2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-(1-(5-(...)
Affinity DataEC50:  44nMAssay Description:Inhibition of HDAC in human HeLa cells using FLUOR DE LYS-SIRT1 as fluorogenic substrate incubated for 4 hrs by spectrophotometer based analysisMore data for this Ligand-Target Pair
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LigandPNGBDBM50612449(CHEMBL5271471)
Affinity DataEC50:  50nMAssay Description:Inhibition of HDAC in human HeLa cells using FLUOR DE LYS-SIRT1 as fluorogenic substrate incubated for 4 hrs by spectrophotometer based analysisMore data for this Ligand-Target Pair
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LigandPNGBDBM50613794(CHEMBL5290710)
Affinity DataEC50:  50nMAssay Description:Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha6-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as increa...More data for this Ligand-Target Pair
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TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM25118((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Affinity DataEC50:  51nMAssay Description:Inhibition of PDGFRbeta phosphorylation expressed in human KM12L4A cells Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataEC50:  90nMAssay Description:Activation of caspase 3/7 in human 22Rv1 cells by Caspase-Glo reagent based analysisMore data for this Ligand-Target Pair
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LigandPNGBDBM50612450(CHEMBL5279520)
Affinity DataEC50:  94nMAssay Description:Inhibition of HDAC in human HeLa cells using FLUOR DE LYS-SIRT1 as fluorogenic substrate incubated for 4 hrs by spectrophotometer based analysisMore data for this Ligand-Target Pair
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LigandPNGBDBM50369240(GANAXOLONE)
Affinity DataEC50:  100nMAssay Description:Positive allosteric modulation of human GABAA alpha2beta1gamma2 receptor expressed in Xenopus laevis oocytes by two-microelectrode voltage-clamp assa...More data for this Ligand-Target Pair
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LigandPNGBDBM50614577(CHEMBL5285443)
Affinity DataEC50:  100nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50612447(CHEMBL5285293)
Affinity DataEC50:  125nMAssay Description:Inhibition of HDAC in human HeLa cells using FLUOR DE LYS-SIRT1 as fluorogenic substrate incubated for 4 hrs by spectrophotometer based analysisMore data for this Ligand-Target Pair
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LigandPNGBDBM50612452(CHEMBL5285418)
Affinity DataEC50:  138nMAssay Description:Inhibition of HDAC in human HeLa cells using FLUOR DE LYS-SIRT1 as fluorogenic substrate incubated for 4 hrs by spectrophotometer based analysisMore data for this Ligand-Target Pair
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LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataEC50:  150nMAssay Description:Activation of caspase 3/7 in human 22Rv1 cells by Caspase-Glo reagent based analysisMore data for this Ligand-Target Pair
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TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50304203(2-(4-(6-methoxy-7-(3-(4-methylpiperazin-1-yl)propo...)
Affinity DataEC50:  170nMAssay Description:Inhibition of PDGFRbeta in human HCT116 cells by cellular phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50615577(CHEMBL5281882)
Affinity DataEC50:  200nMAssay Description:Positive allosteric modulation of human GABAA alpha2beta1gamma2 receptor expressed in Xenopus laevis oocytes by two-microelectrode voltage-clamp assa...More data for this Ligand-Target Pair
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LigandPNGBDBM50369240(GANAXOLONE)
Affinity DataEC50:  200nMAssay Description:Positive allosteric modulation of human GABAA alpha1beta2gamma2 receptor expressed in Xenopus laevis oocytes by two-microelectrode voltage-clamp assa...More data for this Ligand-Target Pair
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LigandPNGBDBM50612453(CHEMBL5285433)
Affinity DataEC50:  208nMAssay Description:Inhibition of HDAC in human HeLa cells using FLUOR DE LYS-SIRT1 as fluorogenic substrate incubated for 4 hrs by spectrophotometer based analysisMore data for this Ligand-Target Pair
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LigandPNGBDBM50614548(CHEMBL5273275)
Affinity DataEC50:  250nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50614570(CHEMBL5267062)
Affinity DataEC50:  310nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Affinity DataEC50:  400nMAssay Description:Positive allosteric modulation of rat recombinant GABAA alpha6beta3gamma2 receptor expressed in Xenopus laevis oocytes assessed as increase in GABA-i...More data for this Ligand-Target Pair
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LigandPNGBDBM50612444(CHEMBL5285266)
Affinity DataEC50:  412nMAssay Description:Inhibition of HDAC in human HeLa cells using FLUOR DE LYS-SIRT1 as fluorogenic substrate incubated for 4 hrs by spectrophotometer based analysisMore data for this Ligand-Target Pair
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LigandPNGBDBM50612448(CHEMBL5268361)
Affinity DataEC50:  430nMAssay Description:Inhibition of HDAC in human HeLa cells using FLUOR DE LYS-SIRT1 as fluorogenic substrate incubated for 4 hrs by spectrophotometer based analysisMore data for this Ligand-Target Pair
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LigandPNGBDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataEC50:  450nMAssay Description:Activation of human Kir6.2/SUR1 channel outward current expressed in HEK293 cells at -70 mV holding potential by EPC9 patch-clamp amplifier based ass...More data for this Ligand-Target Pair
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LigandPNGBDBM50614547(CHEMBL5273292)
Affinity DataEC50:  460nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50614559(CHEMBL5291259)
Affinity DataEC50:  530nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50614565(CHEMBL5291159)
Affinity DataEC50:  550nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50614568(CHEMBL5270996)
Affinity DataEC50:  560nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50614571(CHEMBL5270814)
Affinity DataEC50:  570nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50612446(CHEMBL5270878)
Affinity DataEC50:  610nMAssay Description:Inhibition of HDAC in human HeLa cells using FLUOR DE LYS-SIRT1 as fluorogenic substrate incubated for 4 hrs by spectrophotometer based analysisMore data for this Ligand-Target Pair
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LigandPNGBDBM50614549(CHEMBL5286136)
Affinity DataEC50:  660nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Affinity DataEC50:  700nMAssay Description:Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha6-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as increa...More data for this Ligand-Target Pair
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LigandPNGBDBM50614561(CHEMBL5269505)
Affinity DataEC50:  710nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50614560(CHEMBL5280182)
Affinity DataEC50:  710nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataEC50:  750nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50614550(CHEMBL5283421)
Affinity DataEC50:  780nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50612451(CHEMBL5273223)
Affinity DataEC50:  873nMAssay Description:Inhibition of HDAC in human HeLa cells using FLUOR DE LYS-SIRT1 as fluorogenic substrate incubated for 4 hrs by spectrophotometer based analysisMore data for this Ligand-Target Pair
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